Ph.D. Niigata University of Pharmacy and Applied Life Sciences
M.S. Niigata University of Pharmacy and Applied Life Sciences
B.S. Niigata University of Pharmacy and Applied Life Sciences
1. Human mesenchymal stem cells (hMSCs) have been widely studied as a source of primary adult stem cells for cell therapy because of their multi differentiation potential. hMSC is also known to have immune-regulatory and antimicrobial activities. However, the antimicrobial activities of MSCs have been identified in fields other than orthopaedics. Infection is the most challenging issue. If there is a long delay in diagnosis or treatment, there can be severe damage to the bone or surrounding soft tissues. Therefore, I am investigating on the antimicrobial effects of hMSCs on orthopaedic infectious diseases.
2. Reactive oxygen species and reactive nitrogen species have been implicated in chondrocyte senescence and cartilage aging, pathogenesis of osteoarthritis and rheumatoid arthritis. Naturally occurring polyphenolic compounds (polyphenols) have been known for their anti-inflammatory and chondroprotective effects. However, the potential protective effects of these polyphenols against oxidative stress in chondrocytes are still unclear. I am focusing the anti-oxidative effect of polyphenols on chondrocytes.