Kalon Overholt

Undergraduate Student
Undergraduate Student
Kjo34@pitt.edu

Biography

Education

Pursuing a B.S. in Bioengineering with minors in Physics and Chemistry at the Swanson School of Engineering, University of Pittsburgh.

 

Research Interest

I am working with Dr. Riccardo Gottardi to engineer an in vitro tissue model of the articular bone-cartilage interface. We are using a high-throughput bioreactor to create a “joint-on-a-chip” microenvironment consisting of cartilage and bone for studying the progression of osteoarthritis (OA).  I aim to better define the biochemical interactions between bone and cartilage that occur during OA using this unique high-throughput system. Specifically, I am interested in mimicking a catabolic OA pathway within our stem cell-based model using the inflammatory cytokine TNF-α. Another goal of my research is to compare the biochemical responses of engineered and native tissues to OA-like catabolic events. This comparison will serve as evidence that engineered tissue constructs are physiologically relevant models to study osteoarthritis at the bone-cartilage interface.

 

Mentor: Dr. Riccardo Gottardi

Awards

  • Swanson School of Engineering Summer Research Fellowship 2016