M.D., Ph.D., University of Mississippi Medical Center
B.S. Sports Medicine, Belhaven University
Heterotopic ossification in post-traumatic mouse model:
Heterotopic ossification (HO), the abnormal formation of bone outside of the osseous skeleton, can be subdivided into two broad categories: acquired and hereditary. Acquired HO is precipitated by physical trauma (such as fracture, joint replacement, direct muscular trauma, and burns) or central nervous system trauma. HO is abnormally frequent in patients that experience neurologic trauma and limb amputations, particularly in the context of poly-trauma. Patients who develop HO often must undergo one or more excision procedures and suffer from significant long term pain and rehabilitation. The exact etiology of HO remains unknown. While radiotherapy and indomethacin have been described as appropriate clinical prophylaxis against HO at certain anatomic points, there are no reliable prevention or treatment approaches for this condition. Research work active in our lab seeks to further understand the pathophysiology of HO formation, and looks to utilize molecular inhibitors to decrease HO formation in animal model.
Other research interests: Orthopedic implant infection, biofilm formation, treatment of prosthetic joint infections