Articular cartilage is a highly specialized tissue that protects the bones of diarthrodial joints from forces associated with load bearing, friction and impact. Although a remarkably durable tissue, once articular cartilage is injured, it has very limited capacities for self-repair. Despite the large number of active research and drug discovery programs, no target or therapy has been identified which significantly reduced the progression of osteoarthritis. We utilize a combination of impact, compression, tension and chemical models of OA induction to test the efficacy of newly identified chemicals in slowing or halting the pathogenic processes of OA.
- Peter G Alexander
- Riccardo Gottardi